EAP Protocol

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Information
Drug Name
EAP Protocol
Description
Entry(CIViC)
3
CIViC
Disease Mutation EL ET ED CS VO TR Pubmed Links
stomach carcinoma TP53 p.Arg175His (p.R175H)
( ENST00000510385.5, ENST00000504937.5, ENST00000604348.6, ENST00000576024.2, ENST00000445888.6, ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000455263.6, ENST00000420246.6, ENST00000504290.5, ENST00000714357.1, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) TP53 p.Arg175His (p.R175H)
( ENST00000359597.8, ENST00000269305.9, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) 		C Predictive Supports Sensitivity/Response Somatic 14514923 Detail
stomach carcinoma TP53 p.Arg282Leu (p.R282L)
( ENST00000618944.4, ENST00000445888.6, ENST00000504937.5, ENST00000714408.1, ENST00000576024.2, ENST00000610623.4, ENST00000455263.6, ENST00000620739.4, ENST00000359597.8, ENST00000714409.1, ENST00000413465.6, ENST00000714356.1, ENST00000714359.1, ENST00000622645.4, ENST00000504290.5, ENST00000714357.1, ENST00000610538.4, ENST00000610292.4, ENST00000619186.4, ENST00000619485.4, ENST00000420246.6, ENST00000604348.6, ENST00000269305.9, ENST00000510385.5 ) TP53 p.Arg282Leu (p.R282L)
( ENST00000610538.4, ENST00000610623.4, ENST00000269305.9, ENST00000359597.8, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) 		C Predictive Supports Sensitivity/Response Somatic 14514923 Detail
stomach carcinoma TP53 p.Arg213Pro (p.R213P)
( ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610623.4, ENST00000618944.4, ENST00000269305.9, ENST00000359597.8, ENST00000620739.4, ENST00000619485.4, ENST00000622645.4, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000610292.4, ENST00000610538.4, ENST00000619186.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) TP53 p.Arg213Pro (p.R213P)
( ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) 		C Predictive Supports Sensitivity/Response Somatic 14514923 Detail
Annotation
Description Associated Genes Associated Variants Sensitivity Supported Source Links
In a study of 25 patients with advanced gastric ca... TP53 TP53 p.Arg175His (p.R175H)
( ENST00000510385.5, ENST00000504937.5, ENST00000604348.6, ENST00000576024.2, ENST00000445888.6, ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000455263.6, ENST00000420246.6, ENST00000504290.5, ENST00000714357.1, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) TP53 p.Arg175His (p.R175H)
( ENST00000359597.8, ENST00000269305.9, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) 		Sensitivity true CIViC Evidence detail
In a study of 25 patients with advanced gastric ca... TP53 TP53 p.Arg282Leu (p.R282L)
( ENST00000618944.4, ENST00000445888.6, ENST00000504937.5, ENST00000714408.1, ENST00000576024.2, ENST00000610623.4, ENST00000455263.6, ENST00000620739.4, ENST00000359597.8, ENST00000714409.1, ENST00000413465.6, ENST00000714356.1, ENST00000714359.1, ENST00000622645.4, ENST00000504290.5, ENST00000714357.1, ENST00000610538.4, ENST00000610292.4, ENST00000619186.4, ENST00000619485.4, ENST00000420246.6, ENST00000604348.6, ENST00000269305.9, ENST00000510385.5 ) TP53 p.Arg282Leu (p.R282L)
( ENST00000610538.4, ENST00000610623.4, ENST00000269305.9, ENST00000359597.8, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) 		Sensitivity true CIViC Evidence detail
In a study of 25 patients with advanced gastric ca... TP53 TP53 p.Arg213Pro (p.R213P)
( ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610623.4, ENST00000618944.4, ENST00000269305.9, ENST00000359597.8, ENST00000620739.4, ENST00000619485.4, ENST00000622645.4, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000610292.4, ENST00000610538.4, ENST00000619186.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) TP53 p.Arg213Pro (p.R213P)
( ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 ) 		Sensitivity true CIViC Evidence detail